Limited research has been done among pregnant people participating in investigational drug trials. To enhance the ethical understanding of pregnant people’s perspectives on research participation, we sought to describe motives and risk perceptions of participants in a phase 1 trial of ledipasvir/sofosbuvir treatment for chronic Hepatitis C virus during pregnancy. Pregnant people with chronic HCV infection enrolled in an open-label, phase 1 study of LDV/SOF participated in semi-structured, in-depth interviews to explore their reasons for participation and experiences within the study. (...) Pregnant people took 12 weeks of LDV/SOF and were interviewed at enrollment and at the end of study. We recorded the interviews, transcribed them verbatim, coded them using NVivo software, and performed inductive thematic analysis. Nine women completed the study yielding 18 interview transcripts. We identified two themes regarding motives and one regarding risk perception. Motives— Women conceptualized study participation as part of the caregiving role they associate with motherhood; participating was viewed as an act of caregiving for their infants, their families, themselves, and other pregnant women with chronic HCV. Women also noted that they faced multiple barriers to treatment prior to pregnancy that created a desire to receive therapy through trial participation. Risk perception— Women acknowledged personal and fetal risk associated with participation. Acceptance of risk was influenced by women’s concepts of motherhood, preexisting knowledge of HCV and medical research, family members, intimate partners, or by the study design. Women enrolled in a phase 1 trial for chronic HCV therapy during pregnancy acknowledged risks of participation and were motivated by hopes for fetal and personal benefit and by lack of prenatal access to treatment. Ethical inclusion of pregnant people in research should acknowledge structural factors that contribute to vulnerability and data deficiencies for treatment in pregnancy. (shrink)

Research Ethics, Volume 18, Issue 2, Page 132-150, April 2022. Limited research has been done among pregnant people participating in investigational drug trials. To enhance the ethical understanding of pregnant people’s perspectives on research participation, we sought to describe motives and risk perceptions of participants in a phase 1 trial of ledipasvir/sofosbuvir treatment for chronic Hepatitis C virus during pregnancy. Pregnant people with chronic HCV infection enrolled in an open-label, phase 1 study of LDV/SOF participated in semi-structured, in-depth interviews to (...) explore their reasons for participation and experiences within the study. Pregnant people took 12 weeks of LDV/SOF and were interviewed at enrollment and at the end of study. We recorded the interviews, transcribed them verbatim, coded them using NVivo software, and performed inductive thematic analysis. Nine women completed the study yielding 18 interview transcripts. We identified two themes regarding motives and one regarding risk perception. Motives— Women conceptualized study participation as part of the caregiving role they associate with motherhood; participating was viewed as an act of caregiving for their infants, their families, themselves, and other pregnant women with chronic HCV. Women also noted that they faced multiple barriers to treatment prior to pregnancy that created a desire to receive therapy through trial participation. Risk perception— Women acknowledged personal and fetal risk associated with participation. Acceptance of risk was influenced by women’s concepts of motherhood, preexisting knowledge of HCV and medical research, family members, intimate partners, or by the study design. Women enrolled in a phase 1 trial for chronic HCV therapy during pregnancy acknowledged risks of participation and were motivated by hopes for fetal and personal benefit and by lack of prenatal access to treatment. Ethical inclusion of pregnant people in research should acknowledge structural factors that contribute to vulnerability and data deficiencies for treatment in pregnancy. (shrink)

El objetivo del estudio fue sistematizar y analizar el pensamiento filosófico de Bruno sobre la concepción de magia en el renacimiento. La importancia de la investigación fue entender la cosmovisión bruneana que sigue vigente en el desarrollo del avance de la ciencia. Siendo la conclusión que el concepto de mago es equivalente a sabio, y se manifiesta a través de los tipos de magia: Divina, Física, Matemática y en función del vínculo entre el mago y la naturaleza: magia natural, fantasmagórica, (...) magia natural por virtud, magia matemática, de los desamparados, nigromancia, maléfico, adivinación y profecía. (shrink)

El objetivo del estudio fue sistematizar y analizar la revisión teórica que fundamenta la experiencia pedagógica y el método socializado de los estudiantes de educación superior. El enfoque del estudio fue cualitativo, tipo de investigación revisión de literatura, diseño narrativo, considerando criterios de similitud en las diversas teorías revisadas en artículos de alto impacto, además, de utilizar las estrategias de diagrama de árbol y la estrategia de investigación activa (DIA). Se concluye que existe incipiente uso del método socializado; carencia de (...) autorreflexión; poco análisis reflexivo en la experiencia pedagógica del estudiante de la formación inicial docente (FID). (shrink)

La conciencia de que existe un mundo sublunar y, al mismo tiempo, la de que existe un principio divino en ese mismo mundo, introduce al sistema barroco español (y a sus variadas cohortes de legitimadores) en una modernidad que viene a ser la de una época de radical complejidad. La metáfora de las pirámides, que se puede remontar hasta Nicolás de Cusa, expresa la doble constitución de lo humano y su dificultad extrema para desenvolverse en los mundos de la vida. (...) Abrazar la globalidad en su variedad infinita, implica una teopolítica que ha sido objetivo expreso de la Monarquía Católica hispana. «Monarquía compuesta» que se mostró —especialmente durante el siglo XVII— como un sistema que incluía la diversidad del mundo en el horizonte del trasmundo. (shrink)

En estos tiempos de orgía cultural generalizada, Biblioclasmo es un texto producto de una tradición escéptica; un tratado de «filología negativa»; un ejercicio de controversia, plagado de consideraciones intempestivas.

8 March, now known as International Women’s Day, is a day for feminist claims where demonstrations are organized in over 150 countries, with the participation of millions of women all around the world. These demonstrations can be viewed as collective rituals and thus focus attention on the processes that facilitate different psychosocial effects. This work aims to explore the mechanisms involved in participation in the demonstrations of 8 March 2020, collective and ritualized feminist actions, and their correlates associated with personal (...) well-being and collective well-being, collective efficacy and collective growth, and behavioral intention to support the fight for women’s rights. To this end, a cross-cultural study was conducted with the participation of 2,854 people from countries in Latin America and Europe, with a retrospective correlational cross-sectional design and a convenience sample. Participants were divided between demonstration participants and non-demonstrators or followers who monitored participants through the media and social networks. Compared with non-demonstrators and with males, female and non-binary gender respondents had greater scores in mechanisms and criterion variables. Further random-effects model meta-analyses revealed that the perceived emotional synchrony was consistently associated with more proximal mechanisms, as well as with criterion variables. Finally, sequential moderation analyses showed that proposed mechanisms successfully mediated the effects of participation on every criterion variable. These results indicate that participation in 8M marches and demonstrations can be analyzed through the literature on collective rituals. As such, collective participation implies positive outcomes both individually and collectively, which are further reinforced through key psychological mechanisms, in line with a Durkheimian approach to collective rituals. (shrink)

The contribution of this book to the field of reconciliation is both theoretical and practical, recognizing that good theory guides effective practice and practice is the ground for compelling theory. Using a Girardian hermeneutic as a starting point, a new conceptual Gestalt emerges in these essays, one not fully integrated in a formal way but showing a clear understanding of some of the challenges and possibilities for dealing with the deep divisions, enmity, hatred, and other effects of violence. By situating (...) discourse about reconciliation within the context of Girardian thought, it becomes clear that like Peter who vowed he would never deny Jesus but ended up doing it three times any of us is susceptible to the siren call of angry resentment and retaliation. It is with a profound awareness of the power of violence that the emergence of mimetic discourse around reconciliation takes on particular urgency.". (shrink)

The contribution of this book to the field of reconciliation is both theoretical and practical, recognizing that good theory guides effective practice and practice is the ground for compelling theory. Using a Girardian hermeneutic as a starting point, a new conceptual Gestalt emerges in these essays, one not fully integrated in a formal way but showing a clear understanding of some of the challenges and possibilities for dealing with the deep divisions, enmity, hatred, and other effects of violence.

If a trademark becomes a generic term, it may be cancelled under trademark law, a process known as genericide. Typically, in genericide cases, consumer surveys are brought into evidence to establish a mark’s semantic status as generic or distinctive. Some drawbacks of surveys are cost, delay, small sample size, lack of reproducibility, and observer bias. Today, however, much discourse involving marks is online. As a potential complement to consumer surveys, therefore, we explore an artificial intelligence approach based chiefly on word (...) embeddings: mathematical models of meaning based on distributional semantics that can be trained on texts selected for jurisdictional and temporal relevance. After identifying two main factors in mark genericness, we first offer a simple screening metric based on the ngram frequency of uncapitalized variants of a mark. We then add two word embedding metrics: one addressing contextual similarity of uncapitalized variants, and one comparing the neighborhood density of marks and known generic terms in a category. For clarity and validation, we illustrate our metrics with examples of genericized, somewhat generic, and distinctive marks such as, respectively, DUMPSTER, DOBRO, and ROLEX. (shrink)

Este artigo tem a pretensão de analisar a construção de alguns processos conceituais que levaram a justificativa da legitimação da dominação, subjugação e eliminação do corpo de seres humanos de pele escura, especificamente procedentes do continente africano e as respectivas terras para onde foram levados a força para serem escravizados. Ao receber a alcunha de negro pelo colonizador europeu, o africano começa a ser inserido em um estágio de construção de não-ser, não-humanidade e não-racionalidade. Classificado dessa forma o seu corpo (...) (a força de trabalho) foi utilizado como combustível para o desenvolvimento do capitalismo. Um corpo que poderia ser utilizado e descartado assim que se tornasse inútil para ser explorado. Mesmo após o sistema econômico escravagista ter sido extinto, as estratégias de eliminação do corpo negro não cessaram. Agora, como ameaça biológica, os sistemas políticos contemporâneos, atualizando técnicas coloniais executam esse mesmo corpo em forma de necropolítica. (shrink)

A cross-linguistic/cultural study of verbal metaphor compares responses to terrorism in the UK (N = 96) and to urban violence in Brazil (N = 11). Focus groups discussed how violence changes perceptions of risk, decisions of daily life, and attitudes to others. Metaphor vehicles were identified in transcribed data, then grouped together semantically; 15 vehicle groupings were used with similar frequencies, 16 groupings more in UK data, 14 more in Brazil data. Systematic and framing metaphors were found inside vehicle groupings. (...) A small set of frequent verbal metaphors work as predicted by conceptual metaphor theory. Other verbal metaphor vehicles work much more specifically, as posited by discourse dynamics theory, metaphorizing contextually distinct aspects of living with violence. Major differences were found in responses to violence: UK participants demonstrate feelings of powerlessness and lack of agency through metaphor vehicles relating to Games of Chance, the Concealed nature of terrorist activity, and Body Postures negatively evaluating response from the authorities; Brazilian participants use metaphor vehicles of Violence to emphasize how the threat of urban violence itself becomes a powerful social force that constrains daily activities. (shrink)

En este texto se analiza la importancia de la construcción o el fortalecimiento de la autoridad y confianza epistémicas desde la perspectiva de primera persona de las mujeres y cómo estas cualidades se pueden explorar en su íntima conexión con la confianza corporizada. Las mujeres, a través de sus experiencias particulares de sí mismas, del mundo y de los otros, asimilan de manera perjudicial la desconfianza epistémica que su comunidad de conocimiento les transmite. Se desarrolla esta tesis con base en (...) la concepción fenomenológica de cuerpo vivido, tal como fue planteada por Merleau-Ponty, pero con un énfasis en los trabajos de Simone de Beauvoir e Iris Young, pues son estos los que permiten comprender cómo las estructuras fundamentales de la experiencia y los modos de ser corporizados de las mujeres recorren una ruta experiencial diferente a la de los hombres en razón del tipo de sociedad en que se encuentran. En la parte final del texto se propone una manera de reconstruir o fortalecer la confianza y autoridad epistémicas de las mujeres a partir de una ruta de autoconocimiento corporizado y del cambio de hábitos. (shrink)

Reseña: Omar García Corona. Una crítica descolonial de la Escuela de Frankfurt. Buenos Aires, Poliedro – Editorial de la Universidad de San Isidro, 2021.

This paper aims to offer an analysis of the critique of reason developed by Max Horkheimer and Theodor W. Adorno in three of his most important books: Dialectic of Enlightenment, The critique of instrumental reason and Minima Moralia. Two fundamental questions are posed: Does the thought of the authors set a radical critique? If this is the case, wouldn't it imply a series of meta theorical problems and contradictions? In order to treat these questions, the statement is divided into two (...) parts. The first explores the recurring issues of the critique of reason. In the second, we elaborate a brief reconstruction of two opposite hermeneutics of Horkheimer and Adorno's works: on the one hand, the lecture of Frankfurt School's second generation ; on the other hand, Juan José Sánchez's exposition. Our principal contribution to this debate is to warn Sánchez that, in his justified intention of separating from Habermas and postmodern's reading, he finally weakens the contradictory and negative tone of Adorno and Horkheimer's philosophy.La temática que se aborda en este artículo es la crítica a la razón elaborada por Max Horkheimer y Theodor W. Adorno en tres obras fundamentales: Dialéctica de la Ilustración, Crítica de la razón instrumental y Minima Moralia. Las preguntas que se buscan responder son las siguientes: ¿Constituye el pensamiento conjunto de los autores una crítica radical? Si así fuera, ¿no implicaría una serie de problemas meta teóricos y contradicciones ? El escrito se divide en dos partes. En la primera se abordan los motivos recurrentes de la crítica a la razón. En la segunda, se elabora una sucinta reconstrucción de dos interpretaciones contrapuestas de las obras mencionadas: por un lado, la de los miembros de la segunda generación de la Escuela de Frankfurt, en particular la de Jürgen Habermas y la de Albrecht Wellmer; por otro lado, la del comentarista español Juan José Sánchez. El aporte teórico de este artículo consiste en advertirle a este último autor que, en su justificado afán de distanciarse de la lectura habermasiana y de la postmoderna, termina debilitando el tono contradictorio y negativo de la filosofía conjunta de Adorno y Horkheimer. (shrink)

En el presente trabajo reconstruyo las reflexiones realizadas por Hannah Arendt en sus Conferencias sobre la filosofía política de Kant. Específicamente, pondré el foco de la atención en la concepción de mentalidad amplia y cómo esta concepción se relaciona con otras ideas que Arendt recupera de la Crítica del juicio y que terminan amalgamándose con su propuesta filosófica. En este punto se suscita un problema que es menester señalar. Se trata de una tensión o contradicción que se produce en las (...) Conferencias entre la idea kantiana de mentalidad amplia y la exhortación que hace la autora a elegir activamente –tanto en política, filosofía y arte, como en la vida en general– las preferencias y las compañías. En el artículo arriesgaré una hipótesis de lectura que podría en principio disolver esa tensión, a saber: que si bien es preciso, en momentos críticos, contar con algún tipo de criterio respecto a qué perspectivas deben ser tomadas en cuenta en virtud de una amplitud de miras y cuáles no –por ejemplo, entre quienes tienen capacidad para juzgar y quienes no la tienen–, pasado dicho momento esos criterios deben revisarse y ponerse en tela de juicio. De lo contrario, se corre el riesgo de desvirtuar la idea kantiana de mentalidad amplía restringiéndola en función de nuestras preferencias. (shrink)

During the 1990s, the Government of Peru began to aggressivelyprivatize agriculture. The government stopped loaning money to farmers' cooperatives and closed the government rice-buying company. The government even rented out most of its researchstations and many senior scientists lost their jobs. As part of this trend, the government eliminated its seed certification agency. Instead, private seed certification committees were set up with USAID funding and technical advise from a US university. The committees were supposed to become self-financing (bycertifying seed grown (...) by small seed producers) and each committee was supposed to encourage the development of a group of small seed-producing firms, clustered around the seedcertification agency. The amazing thing is that many of the seed committees actually accomplished these goals. The agronomists who staffed the committees stood by their jobs,even after US funding ended, even though the committees' income was (at best) modest, and occasionally under the threat of violence from the extreme left. Some seed certificationcommittees failed and others did not. Some of the problems with Peruvian agricultural liberalization can be seen in regard to the seed programs of maize, rice, potatoes, and beans. For example, the government abandoned most research, yet could not resist creating certain distortions in the seed market (e.g.,buying large amounts of seed and distributing them for political ends). (shrink)

A reflection about the originality and contributions of the phenomenological institutional Naples school of philosophy, represented by its major exponent,Gino Capozzi, in relation to the theory of human rights is developed in this paper. His philosophy is explained in his book “Diritti dell´Uomo,..

RESUMEN En este artículo se plantea una discusión con el enfoque doxástico de los delirios. A pesar de que esta línea de análisis ha hecho importantes aportes a la comprensión del fenómeno, tiene dificultades importantes a la hora de aportar un marco explicativo completo de los delirios, porque deja por fuera el aspecto total de la experiencia y sigue basándose implícitamente en la idea de que podemos estudiar de manera separada e independiente los aspectos físicos, cognitivos y experienciales de un (...) fenómeno tan complejo. El artículo propone que, más allá de la decisión acerca de si se debe considerar a los delirios como creencias irracionales o no, o de si se puede concebirlos como creencias en absoluto, es necesario tener en cuenta la drástica transformación del mundo entero de la experiencia que se da en el sujeto delirante, tal como lo plantea la fenomenología. ABSTRACT This article discusses the doxastic approach to delusions. Although this analytic approach has made important contributions to our understanding of the phenomenon, it faces serious difficulties when it comes to providing a complete explanatory framework of delusions, as it leaves out the experiential aspect. This analytic approach continues to be implicitly based on the idea that the physical, cognitive and experiential aspects of such a complex phenomenon can be studied separately. The article suggests that, in addition to merely considering whether or not delusions ought to be taken as irrational beliefs, or even as beliefs at all, it is necessary to take into account the drastic transformation of the entire experiential world of the delusional subject, as suggested by the phenomenological approach. (shrink)

Se examina la relación entre razones y causas de la acción en el psicoanálisis freudiano. Hay acuerdo en que Freud confundía, o por lo menos no hizo una distinción rigurosa a lo largo de su trabajo, entre razones y causas. Se analizarán dos interpretaciones al respecto. De un lado, la que sostiene que había en él una tendencia naturalista y que, en ese sentido, nunca abandonó su pretensión de encontrar las causas de la acción humana; de otro lado, la que (...) defiende que en Freud imperó siempre una orientación más psicologizante, con base en la cual defendió la búsqueda del sentido de actos fallidos, sueños, etc.; lo cual lo llevó a abandonar su orientación cientificista y a concentrarse en la comprensión o interpretación de la acción. Como alternativa se propone considerar que el conflicto en Freud se soluciona si dejamos de lado los dualismos razones / causas y comprensión /explicación. This paper examines the relationship between reasons and causes of action in Freudian psychoanalysis. There is an agreement on the issue that, throughout his work, Freud confused or at least did not make a rigorous distinction between reasons and causes. Two interpretations will be analyzed on this matter. On one hand, a position that holds that there was a naturalistic tendency in Freud and, in that sense, that he never abandoned his aspiration to find the causes of human action. On the other hand, a position that argues that a psychologizing orientation always prevailed in Freud, based on which he defended the search for the meaning of Freudian slips, dreams, etc; which led him to abandon his scientific orientation and to focus on understanding or interpreting the action. As an alternative it is suggested that the conflict in Freud is solved if we discard the dualisms reasons/causes and understanding/explanation. (shrink)

En el presente trabajo abordo la interpretación que Axel Honneth realiza, en su libro Crítica del poder, de la propuesta de Michel Foucault. Honneth señala, a modo de crítica, la existencia de una contradicción entre lo que denomina la teoría del poder de Foucault y sus estudios históricos –en particular, los reunidos en Vigilar y Castigar–. Uno de mis objetivos es explicar esta contradicción y, a partir de ella, proponer una lectura alternativa. En contraposición a Honneth, para quien las instituciones (...) disciplinarias que analiza Foucault terminarían desplazando la acción y la lucha social, intento mostrar –y este es el aporte que busco realizar en el trabajo a partir de una reconstrucción conceptual– que las disciplinas y por añadidura las instituciones disciplinarias deben considerarse tácticas que nunca alcanzan del todo su objetivo. Son tácticas que no logran bloquear, de manera definitiva, las expresiones de resistencia y conflictividad. Esta lectura alternativa que aquí propongo permitiría, en principio, ensayar al menos dos puntos de contacto entre Foucault y la teoría crítica que aún no han sido elucidados. (shrink)

In this article, I present the structural consequences generated by the continuous and systematic epistemic injustices carried out in certain communities or institutions. These injustices contribute to building a structure of silencing, denial of epistemic authority, cover-up and impunity. The importance of the normative aspect that guides the reflections about these injustices will be exposed in two senses: on the one hand, insofar as it is necessary to have criteria that allow establishing the truth in the background of evaluation of (...) epistemic injustices and, on the other, in the sense of specifying how systematically attempting against it produces almost irreversible epistemic damage and guarantees the perpetuation of the structure. It will be shown how this happens within the framework of a powerful institution such as the Catholic Church, which has exhibited a pattern of testimonial injustices and the cover-up of abuses within it for decades. (shrink)

En el presente artículo nos proponemos explicitar cuáles son las principales características que Franz Neumann –autor del círculo “externo” de la primera Teoría Crítica– le atribuye a la dominación socio-política. Para abordar esta cuestión es necesario reseñar algunas de las principales tesis de su clásico libro sobre el nacional-socialismo titulado Behemoth, prestando especial atención a su análisis relativo a la destrucción de la racionalidad jurídica. Nos interesa, puntualmente, responder a la siguiente pregunta: ¿hay en su propuesta una concepción de dominación (...) que presuponga, además de coerción, consentimiento y participación de los grupos dominados? Para poder dar cuenta de las distintas aristas que detenta este interrogante, consideramos necesario retomar los aportes que hace Axel Honneth –uno de los tantos teóricos contemporáneos que instan a recuperar los estudios de Neumann– en su libro Crítica del poder, donde hace mención a la existencia de “relaciones bilaterales de dominio”. Aquí veremos que Neumann ofrece precisiones para responder al problema de la “dominación bilateral” –así lo llamaremos–, pero con limitaciones nada desdeñables. Limitaciones que, y ésta es una sugerencia que haremos al final del artículo, podrían sortearse a partir de un diálogo más abarcador que involucre a otros miembros del círculo “externo”. (shrink)